Acne It occurs in places that have the highest density of active fat-producing glands. Acne It usually appears on the face, back and arms and is occasionally seen on the limbs. The sebaceous gland is important in the context of its effects on the hair-fat unit. The hair-fat unit is a set of sebaceous glands and hair follicles attached to it, sebum is the main substance produced in the sebaceous glands and a kind of lipid (fat) or Acne Is. Some sebum triglycerides by P. Acnes are converted to free fatty acids, which create an environmental dimension that P. Acnes grow and multiply easily in it. Squalene and some fatty acids play an important role in the cause and effect of acne.
It is also known that sebum in people with acne has relatively little linoleic acid. Linoleic acid is a free fatty acid that the skin needs to help regenerate and properly exfoliate.
In animal models that do not have enough linoleic acid, the skin becomes scaly. You can think of an acne lesion as a large scale inside the follicle. People with acne have a group that has larger sebaceous glands and more sebum produced in their skin, diluting linoleic acid inside the follicle, thus disrupting normal peeling and helping to create micro-comedos.
Overproduction of sebum is the first abnormality that occurs at the onset of acne and is usually followed by abnormal shedding of skin cells covering the pores and then the formation of micro-comedos. Sebum is a commodosa. Inflammation was also found in studies in which sebum was injected into the skin. Therefore, sebum is both an inflammatory and a comedose substance.
In people prone to acne, from about the age of 7 to 8, the size of the sebaceous gland increases and becomes more prominent in response to increased production of hormones called androgens. This process is associated with increased secretion of sebum or sebaceous glands. The hormonal changes that follow puberty cause changes in the sebaceous glands and skin cells that line the pores of the hair follicle. There are also factors that control how the sebaceous glands react to hormones. These factors cause more hormones to affect some people. This is where inheritance comes into play. In acne, overproduction of sebum is mainly due to differences in the single hair-fat reaction to the topical environment, increased circulating androgens, or both. This is because acne needs to be considered from several different angles, even if there is no measurable hormonal imbalance. For this reason, acne improves in women who have no measurable hormonal abnormalities when they take oral contraceptives for other reasons.
Source: May Show